Cantonese, Mandarin and English

Chinese and English

Chemistry and molecular pharmacology of Chinese Medicine, Chemical Biology, Resolution of Inflammation, Adverse Tissue Remodeling, and Innate Immunity in Myocardial Infarction, Obesity, Diabetes, Neurodegenerative Diseases

BSc, MSc, PhD

Professor Rong is currently an Associate Professor in Molecular Pharmacology of Chinese Medicines and works on the following four aspects: 1) Designing curriculum, writing textbook chapters, and teaching several courses including Life Sciences, Chemistry and Pharmacology of Chinese Medicines for undergraduate and post-graduate students. 2) Supervising MPhil/PhD/Final-Year undergraduate students in chemistry, biochemistry chemical biology and pharmacology of Chinese Medicines; Applying research grants including Seed Fund, GRF, HMRF, MRP and NSFC grants; Examining MPhil/PhD thesis; 3) Administrative service including Lab Safety management, internal GRF proposal evaluation and peer evaluation; 4) Community service including article review for several international peer-reviewed journals, grant review for local universities, NSFC and Macau government, volunteering service for several professional associations including The Society for Hong Kong Scholars.

Dr Rong’s research has been focusing on the molecular characterization of anti-inflammatory, neuroprotective and neurotrophic activities of Chinese medicines towards the development of novel therapies for neurological and cardiovascular diseases. Our research is directed to three categories: 1) Molecular characterization of the cellular responses to complex herbal medicines by integrative genomic, proteomic, cell signaling and chemical biology approaches. Our strategy is to profile the biological responses to complex herbal medicine formulations by RNA-sequencing, DNA microarray and LC/MS-based proteomics. The potential genes or protein targets are selected from the transcriptomic or proteomic profiles in a bias-free manner. 2) Basic mechanisms underlying the neuroprotective, neurorestorative and cardioprotective activities of the bioactive botanicals. Our strategy is to identify the corresponding active compounds from the complex herbal medicine formulations through a bioactivity-guided fractionation procedure against specific disease-relevant molecular targets. 3) Structure-activity relationship of the bioactive botanicals and drug discovery. Our strategy is to develop more potent drug candidates by chemical biology approaches and molecular docking techniques. In the past a few years, we have selected a group of signature genes from transcriptomic and proteomic profiles as new therapeutic targets and quality control metrics. We strive to dissect the interactions between the active compounds in complex herbal medicines and the protein targets for the development of new chemically defined and mechanism-specific medicines. With the support of several GRF, HMRF and NSFC grants, we have successfully discovered the active compounds for the regulation of heme oxygenase-1 (HO-1), NADP-dependent leukotriene B4 12-hydroxydehydrogenase (LTB4DH), arginase-2, calreticulin, GRP78 and PKM2. The experimental results have been published as more than 60 papers and four international patents.

• Post-graduate courses:
• 1. Current Research and Development of Chinese Medicines” (MMPH6187)
• 2. Herb-Drug Interactions” (MSCM6602)
• 3. Chemistry of Chinese Medicine and Natural Products” (MSCM6503)
• 4. Medical Statistics (MCHM 6303)

• Undergraduate courses:
• 1. Biochemistry” (BCHM1017)
• 2. Introduction to Herbal Resources” (BCHM9002)
• 3. System Biology for Chinese Medicine Research (BCHM1905)
• 4. Enrichment Biology
• 5. Chinese Medicine Theory and Quality Control for Chinese Medicines” (BCHM1903)
• 6. Life Sciences BMSC1101, BMSC2101, BMSC2203, BMSC3104

• Peer-Reviewed Journals
• 1 .Molecular Neurobiology
• 2. ACS Chemical Neuroscience
• 3. Scientific Reports
• 4. CNS Neuroscience & Therapeutics
• 5. Neuroscience
• 6. Neurochemical Research
• 7 .Neuroscience Letters
• 8. Journal of Ethnopharmacology
• 9. Life Sciences
• 10. Journal of Translational Medicine
• 11. Molecules
• 12. Journal of Pharmacology and Pharmacy
• 13. Evidence-based Complementary and Alternative Medicine
• 14. Journal of Complementary and Integrative Medicine
• 15. International Journal of Molecular Sciences
• 16. Drug and Chemical Toxicology
• 17. Journal of Veterinary and Animal Health
• 18. Oxidative Medicine and Cellular Longevity

• Professional & Community Service
• 1. Executive member, The Hong Kong Scholars Association
• 2. Executive member, The Hong Kong Herbal Medicine Pharmacology Association
• 3. Executive member, Osteoporosis Subgroup, The Chinese Medical Association
• 4. Executive member, Immunology & Metabolism Subgroup, The Chinese Society of Cancers

1. Ni Fan, Jia Zhao, Wei Zhao, Yanting Shen, Qingchun Song, Anderson Ho Cheung Shum, Yu Wang, Jianhui Rong*, Biodegradable celastrol-loaded albumin nanoparticles ameliorate inflammation and lipid accumulation in diet-induced obese mice, Biomaterials Science, 2022 Jan 12. doi: 10.1039/d1bm01637g. Online ahead of print. [IF 6.843]
2. Dan Luo, Ni Fan, Xiuying Zhang, Fung Yin Ngo, Jia Zhao, Wei Zhao, Min Huang, Ding Li, Yu Wang, Jianhui Rong*, Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet-induced obesity, Elife, 2022 Feb 9;11:e72182. doi: 10.7554/eLife.72182. [IF 8.14]
3. Meng W, Lin WL, Yeung WF, Yangbo ZHANG, Ng Ernest HY, Lee Elaine YP, Zhang Z, Rong J, Lao L. Randomized double-blind trial comparing low dose and conventional dose of a modified traditional herbal formula Guizhi Fuling Wan in women with symptomatic uterine fibroids. J Ethnopharmacol. 2021 Sep 22:114676. doi: 10.1016/j.jep.2021.114676.
4. Zhe Zhang, Jianhao Pan, Tao Zhu, Nathalie Malewicz, Kaihe Ye, Jianhui Rong, Yong Luo, Yongli Situ, Alexei Verkhratsky, Yong Wang, Jianhao Zhao, Dan Tang, Hong Nie, Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch, J Pharm Pharmacol. 2021 Dec 7;73(12):1617-1629. doi: 10.1093/jpp/rgab145.
5. Wei Zhao, Jia Zhao, Xiuying Zhang, Ni Fan, Jianhui Rong*, Upregulation of Small Ubiquitin-Like Modifier 2 and Protein SUMOylation as a Cardioprotective Mechanism Against Myocardial Ischemia-Reperfusion Injury, Frontiers in Pharmacology, 13 September 2021 | https://doi.org/10.3389/fphar.2021.731980. [IF 5.81]
6. Zhong Zhang, Guoying Hao, Chen Liu, Junqing Fu, Jianhui Rong*, Xingbin Yang, Recent Progress in the Preparation, Chemical Interactions and Applications of Biocompatible Polysaccharide-Protein Nanogel Carriers, Food Research International, 2021 Sep;147:110564. doi: 10.1016/j.foodres.2021.110564. [IF 6.3]
7. Meng W, Lao L, Zhang ZJ, Lin WL, Zhang YB, Yeung WF, Yu YMB, Ng HYE, Chen JP, Su J, Rong JH, Lam PYF, Lee E. Tumour-shrinking decoction for symptomatic uterine fibroids: a double-blind, randomised, two-dose trial (abridged secondary publication). Hong Kong Med J. 2021 Jun;27 Suppl 2(3):8-10.
8. Jia Zhao, Yizhen Jia, Wei Zhao, Huixin Chen, Xiuying Zhang, Fung Yin Ngo, Dan Luo, Youqiang Song, Lixing Lao, Jianhui Rong*, Botanical drug puerarin ameliorates liposaccharide-induced depressive behaviors in mice via inhibiting RagA/mTOR/p70S6K pathways. Oxidative Medicine & Cellular Longevity, 2021, DOI: 10.1155/2020/5780703. [IF 4.868]
9. Guoying Hao, Zhong Zhang, Xin Ma, Runguang Zhang, Xiaoxiao Qin, Hongxia Sun, Xingbin Yang, Jianhui Rong*, A versatile microfluidic paper chip platform based on MIPs for rapid ratiometric sensing of dual fluorescence signals, Microchemical Journal, Volume 157, 2020,105050.DOI: 10.1016/j.microc.2020.105050 [IF 3.28]
10. Wei Zhao, Xiuying Zhang, Jianhui Rong*, SUMOylation as a therapeutic target for myocardial infarction, Frontiers in Cardiovascular Medicine, 2021 Jul 28;8:701583. doi: 10.3389/fcvm.2021.701583. eCollection 2021. [IF 6.05]
11. Fung Yin Ngo, Weiwei Wang, Qilei Chen, Jia Zhao, Hubiao Chen, Jin-Ming Gao, Jianhui Rong*, Network pharmacology analysis and molecular characterization of herbal medicine formulation Qi-Fu-Yin for the inhibition of neuroinflammatory biomarker iNOS in microglial BV-2 cells: implication for the treatment of Alzheimer’s disease, Oxidative Medicine & Cellular Longevity, 2020 Sep; 2020(1):1-15, DOI: 10.1155/2020/5780703. [IF 4.868]
12. Yingke Zhao, Jia Zhao, Xiuying Zhang, Yuanyuan Cheng, Dan Luo, Simon Ming-Yuen Lee, Lixing Lao, Jianhui Rong, Botanical drug puerarin promotes neuronal survival and neurite outgrowth against MPTP/MPP+-induced toxicity via progesterone receptor signaling, Oxidative Medicine & Cellular Longevity, 2020 Sep; 2020(1):1-15, DOI: 10.1155/2020/5780703. [IF 4.868]
13. Wei Zhao, Jia Zhao, Jianhui Rong*, Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction, Oxidative Medicine & Cellular Longevity, 2020 Sep; 2020(1):1-15, DOI: 10.1155/2020/5780703. [IF 4.868]
14. Guoying Hao, Zhong Zhang, Xin Ma, Runguang Zhang, Xiaoxiao Qin, Hongxia Sun, Xingbin Yang, Jianhui Rong*, A versatile microfluidic paper chip platform based on MIPs for rapid ratiometric sensing of dual fluorescence signals, Microchemical Journal, Volume 157, 2020,105050.DOI: 10.1016/j.microc.2020.105050. [IF 3.28]
15. Yuanyuan Cheng, Dan Luo, Yingke Zhao, Jianhui Rong*, N-Propargyl caffeate amide (PACA) prevents cardiac fibrosis in experimental myocardial infarction by promoting pro-resolving macrophage polarization, Aging (Albany NY). 2020 Oct 16;9(10):2069-2082. doi: 10.18632/aging.101302. [IF 5.515]
16. Zhang Z, Ma X, Li B, Zhao J, Qi J, Hao G, Rong J,* Yang, X*, Fluorescence detection of 2, 4-dichlorophenoxyacetic acid by ratiometric fluorescence imaging on paper-based microfluidic chips. Analyst, 2020 Feb 3;145(3):963-974. DOI: 10.1039/C9AN01798D. [IF 3.98]
17. Zhao J, Lao L, Cui W, Rong J*, Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge. Journal of Neuroinflammation. 2019 Nov 11;16(1):211. doi: 10.1186/s12974-019-1610-5. [IF 5.70]
18. Tong KY, Zhao J, Tse C, Wan P, Rong J and Au-Yeung HY, Selective Catecholamine Detection in Living Cells by a Copper-based Oxidative Reactivity. Chemical Sciences, 2019, 10, 8519-8526. [IF 9.556]
19. Zhao J, Luo D, Zhang Z, Fan N, Wang Y, Nie H, Rong J*, Celastrol-loaded PEG-PCL nanomicelles ameliorate inflammation, lipid accumulation, insulin resistance and gastrointestinal injury in diet-induced obese mice. Journal of Controlled Release, 2019 Sep 28;310:188- 197. [IF 7.901]
20. Yingke Zhao, Dan Luo, Zhipeng Ning, Jianhui Rong*, Lixing Lao, Electro-Acupuncture Ameliorated MPTP-Induced Parkinsonism in Mice via TrkB Neurotrophic Signaling, Frontiers in Neuroscience, 2019 May 14;13:496, https://doi.org/10.3389/fnins.2019.00496. [IF 3.648]
21. Cheng IC, Li RK, Leung GP, Li SL, Kong M, Lao LX, Zhang ZJ, Lin WL, Ng EH, Rong JH, Chen JP, Su J, Zhang KY, Meng W, Application of UPLC-MS/MS to simultaneously detect four bioactive compounds in the tumour-shrinking decoction (FM1523) for uterine fibroids treatment, Phytochemical Analysis. 2019 Jul;30(4):447-455. doi: 10.1002/pca.2827. [IF 1.963]
22. Yuanyuan Cheng*, Jianhui Rong, Pro-resolving lipid mediators as therapeutic leads for cardiovascular diseases, Expert Opinion on Therapeutic Targets, 2019 May;23(5):423-436. doi: 10.1080/14728222.2019.1599360. [Epub ahead of print]. [IF 4.621]
23. Zhong Zhang, Xin Ma, Mengfan Jia, Bowei Li, Jianhui Rong* and Xingbin Yang*, Deposition of CdTe Quantum dots in microfluidic paper chips for rapid fluorescent detection of pesticide 2, 4-D, Analyst, 2019, 144, 1282-1291, doi: 10.1039/c8an02051e. [IF 3.98]
24. Jia Zhao*, Mengxia Zhu, Mukesh Kumar, Fungyin Ngo, Yinhui Li, Lixing Lao, Jianhui Rong, A pharmacological appraisal of neuroprotective and neurorestorative flavonoids against neurodegenerative diseases. CNS Neurol Disord Drug Targets. 2019;18(2):103-114. doi:10.2174/1871527317666181105093834. [Epub ahead of print]. [IF 2.761]
25. Yuanyuan Cheng, Chuanbin Yang, Dan Luo, Xuechen Li, Chris X Le and Jianhui Rong*, N-Propargyl caffeamide skews macrophages towards an M2-like phenotype against myocardial ischemic injury via activating Nrf2/HO-1 pathway and inhibiting NF-κB pathway, Cellular Physiology & Biochemistry, 2018;47(6):2544-2557. doi: 10.1159/000491651. [IF 5.50]
26. Xueyu Wang, Guo-Cai Wang, Jianhui Rong, Shi Wei Wang, Tzi Bun Ng, Yan Bo Zhang, Kai Fai Lee, Lin Zheng, Hei-Kiu Wong, Ken Kin Lam Yung and Stephen Cho Wing Sze, Identification of Steroidogenic Components Derived From Gardenia jasminoides Ellis Potentially Useful for Treating Postmenopausal Syndrome. Frontiers in Pharmacology. 2018 May 30;9:390. doi: 10.3389/fphar.2018.00390. [IF 3.831]
27. Yuanyuan Cheng, Xuechen Li, Hung-Fat Tse and Jianhui Rong*, Gallic acid-L-leucine conjugate protects mice against LPS-induced inflammation and sepsis via correcting pro-inflammatory lipid mediator profiles and oxidative stress, Oxidative Medicine & Cellular Longevity, 2018 Mar 25;2018:1081287. doi: 10.1155/2018/1081287. [IF 4.868]
28. Yuanyuan Cheng, Jianhui Rong*, Macrophage Polarization as a Therapeutic Target in Myocardial Infarction, Current Drug Targets, 2018;19(6):651-662. doi: 10.2174/1389450118666171031115025. [IF 2.642]
29. Dan Luo, Yumeng Guo, Yuanyuan Cheng, Jia Zhao, Yu Wang*, Jianhui Rong*, Natural product celastrol suppressed macrophage M1 polarization against inflammation in diet-induced obese mice via regulating Nrf2/HO-1, MAP kinase and NF-κB pathways, Aging (Albany NY). 2017 Oct 16;9(10):2069-2082. doi: 10.18632/aging.101302. [IF 5.515]
30. Yuanyuan Cheng, Yibin Feng, Zhengyuan Xia, Xuechen Li, Jianhui Rong*, ω-Alkynyl arachidonic acid promotes anti-inflammatory macrophage M2 polarization against acute myocardial infarction via regulating the cross-talk between PKM2, HIF-1α and iNOS, Biochim Biophys Acta- Molecular and Cell Biology of Lipids, 2017 Sep 28;1862(12):1595-1605. doi: 10.1016/j.bbalip.2017.09.009. [IF 4.402]
31. Jing Wei, Yuanyuan Cheng, Wan-Hui Guo, Da-Cheng Wang, Qiang Zhang, Ding Li, Jianhui Rong*, and Jin-Ming Gao*, Molecular diversity and potential anti-neuroinflammatory activities of cyathane diterpenoids from the basidiomycete Cyathus africanus, Scientific Reports, 2017 Aug 21;7(1):8883. doi: 10.1038/s41598-017-09118-z. [IF 4.122]
32. Yuanyuan Cheng, Jianhui Rong*, Therapeutic potential of heme oxygenase-1/carbon monoxide system against ischemia-reperfusion injury. Current Pharmaceutical Design, 2017;23(26):3884-3898. doi: 10.2174/1381612823666170413122439. [IF 2.412]
33. Dan Luo, Jia Zhao, Yuanyuan Cheng, Simon Ming-Yuen Lee, Jianhui Rong*, N-Propargyl caffeamide (PACA) ameliorates dopaminergic neuronal loss and motor dysfunctions in MPTP mouse model of Parkinson’s disease via promoting the conversion of pro-NGF to NGF, Molecular Neurobiology, 2018 Mar;55(3):2258-2267. doi: 10.1007/s12035-017-0486-6. [IF 5.076]
34. Dan Luo, Jia Zhao, Jianhui Rong*, Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins. Phytomedicine. 2016 Dec 1;23(13):1621-1628. doi: 10.1016/j.phymed.2016.10.006. [IF 4.18]
35. Yuanyuan Cheng, Dan Luo, Zhengyuan Xia and Jianhui Rong*, Pharmacokinetic profiles and cardioprotective potential of N-propyl caffeamide (nPCA) in male Sprague-Dawley rats, Arch Immunol Ther Exp (Warsz). 2017 Apr;65(2):145-156. doi:10.1007/s00005-016-0413-y. PMID: 27480649. [IF 3.018]
36. Cheng Y, Tse HF, Li X, Han Y, Jianhui Rong*, Gallic acid-l-leucine (GAL) conjugate enhances macrophage phagocytosis via inducing leukotriene B4 12-hydroxydehydrogenase (LTB4DH) expression. Molecular Immunology. 2016 Jun;74:39-46. doi:10.1016/j.molimm.2016.04.012. [IF 3.064]
37. Cheng Y, Xia Z, Han Y, Jianhui Rong*, Plant Natural Product Formononetin Protects Rat Cardiomyocyte H9c2 Cells against Oxygen Glucose Deprivation and Reoxygenation via Inhibiting ROS Formation and Promoting GSK-3β Phosphorylation. Oxidative Medicine and Cellular Longevity, 2016;2016:2060874. doi: 10.1155/2016/2060874. [IF 4.868]
38. Jia Zhao, Dan Luo, Zhaohui Liang, Lixing Lao, Jianhui Rong*, Plant natural product puerarin ameliorates depressive behaviors and chronic pain in mice with spared nerve injury (SNI), Molecular Neurobiology, 2017 May, 54 (4), 2801–2812. doi:10.1007/s12035-016-9870-x. [IF 5.076]
39. Chuanbin Yang, Yuanyuan Cheng, Jianhui Rong*, Releasing Nrf2 to promote neurite outgrowth, Neural Regeneration Research, 2015 Dec;10(12):1934-5. doi: 10.4103/1673-5374.169618. [IF 2.472]
40. Chuanbin Yang, Jia Zhao, Yuanyuan Cheng, X Chris Le, Jianhui Rong*, N-Propargyl caffeate amide (PACA) potentiates nerve growth factor (NGF)-induced neurite outgrowth and attenuates 6-hydroxydopamine (6-OHDA)-induced toxicity via activating the Nrf2/HO-1 pathway, ACS Chemical Neuroscience, 2015 Sep 16;6(9):1560-9. [IF 4.362].
41. Yuanyuan Cheng, Jia Zhao, Hung Fat Tse, X Chris Le, Jianhui Rong*, Plant natural products calycosin and gallic acid synergistically attenuate neutrophil infiltration and subsequent injury in isoproterenol-induced myocardial infarction: a possible role for leukotriene B4-12-hydroxydehydrogenase? Oxidative Medicine and Cellular Longevity, 2015;2015:434052. [IF 3.516].
42. Jia Zhao, Chuanbin Yang, Yuanyuan Cheng, Sam Lau, Lixing Lao, Bo Shuai, Jing Cai, Jianhui Rong*, Botanical drug puerarin attenuates 6-hydroxydopamine (6-OHDA)-induced neurotoxicity via upregulating mitochondrial enzyme arginase-2, Molecular Neurobiology, 2016 May;53(4):2200-11. doi:  10.1007/s12035-015-9195-1. [IF 5.137].
43. Cheng YY, Yang CB, Zhao J, Tse HF, Rong J*, Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of botanical drug amygdalin, Journal of Nutritional Biochemistry, 2015, 26: 146–154. [IF 4.59].
44. Zhao J, Cheng YY, Fan W, Yang CB, Ye SF, Cui W, Wei W, Lao L, Cai J, Han YF, Rong J*, Botanical drug puerarin coordinates with nerve growth factor in the regulation of neuronal survival and neuritogenesis via activating ERK1/2 and PI3K/Akt signaling pathways in the neurite extension process. CNS Neurosci Ther. 2015 Jan;21(1):61-70. [IF 3.78].
45. Yang CB, Li X, Rong J*, Amygdalin isolated from Semen Persicae (Tao Ren) extracts induces the expression of follistatin in HepG2 and C2C12 cell lines. Chin Med. 2014 Sep 16; 9:23. [IF 2.34].
46. Yang CB, Zhao J, Cheng YY, Li X, Rong J*, Bioactivity-guided fractionation identifies amygdalin as a potent neurotrophic agent from herbal medicine Semen Persicae extract. Biomed Res Int. 2014;2014:306857. [IF 2.71].
47. Shuai B, Yang YP, Shen L, Zhu R, Xu XJ, Ma C, Lv L, Zhao J, Rong JH, Local renin-angiotensin system is associated with bone mineral density of glucocorticoid-induced osteoporosis patients. Osteoporos Int. 2015 Mar;26(3):1063-71. [IF 4.169].
48. Yang CB, Zhao J, Pei WJ, Zheng XH, Rong J*, Biochemical mechanisms of bornyl caffeate induced cytotoxicity in rat pheochromocytoma PC12 cells, Chem Biol Interact, 2014 Jun 5;219C:133-142. [IF 2.98].
49. Cheng YY, Yang CB, Zhao J, Rong J*, Purification of Z-ligustilide by AgNO3-Impregnated Silica Gel, Chinese Journal of Modern Applied Pharmacy, 2014, 2014 May;31(5):552-555.
50. Yang CB, Cheng YY, Zhao J, Rong J*, Recent studies on the  chemistry and biological activities of flavonones, Chinese Journal of International Medicine and Pharmacy, 2014 April;36(4):370-375.
51. Cui W, Zhang ZJ, Hu SQ, Mak SH, Xu DP, Choi CL, Wang YQ, Tsim WK, Lee MY*, Rong JH*, Han YF*, Sunitinib Produces Neuroprotective Effect Via Inhibiting Nitric Oxide Overproduction, CNS Neurosci Ther. 2014 2014 Mar;20(3):244-52. [IF 3.78].
52. Yang CB, Pei WJ, Zhao J, Cheng YY, Zheng XH, Rong J*, Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathways, Acta Pharmacol Sin. 2014 Jan;35(1):113-23. [IF 2.912].
53. Cui W, Hu S, Chan HH, Luo J, Li W, Mak S, Choi TC, Rong J, Carlier PR, Han Y. Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. Chem Biol Interact. 2013 Mar 25;203(1):365-70. [IF 2.982].
54. Cui W, Zhang Z, Li W, Hu S, Mak S, Zhang H, Han R, Yuan S, Li S, Sa F, Xu D, Lin Z, Zuo Z, Rong J, Ma ED, Choi TC, Lee SM, Han Y, The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br J Pharmacol. 2013 Mar;168(5):1201-14. [IF 4.99].
55. Cui W, Zhang Z, Li W, Mak S, Hu S, Zhang H, Yuan S, Rong J, Choi TC, Lee SM, Han Y, Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase. PLoS One. 2012;7(9):e46253. [IF 3.73].
56. Qi H, Han Y, Lau ASY, Rong J*, (Z)-Ligustilide potentiates the neurotoxicity of dopamine in rat dopaminergic neuronal PC12 cells, Neurotoxicity Research, 201222(4):345-354. [IF: 3.02].
57. Qi H, Han Y, Rong J*, Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating neurohormesis of Z-Ligustilide in neuronal PC12 cells against oxygen and glucose deprivation, Neuropharmacology, 2012 62(4) , 1659-1670. [IF: 4.67].
58. Cui W, Li W, Han R, Mak S, Zhang H, Hu S, Rong J, Han Y, PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP(+)-induced neuronal apoptosis, Neurochem Int. 2011 Nov;59(6):945-53. [IF: 3.6].
59. Qi H, Chen B, Le X Chris, Rong J*, Concomitant induction of heme oxygenase-1 attenuates the cytotoxicity of arsenic species from Lumbricus extract in human liver HepG2 cells, Chemistry and Biodiversity, 2012 Apr;9(4):739-54. [IF: 1.9].
60. Wei L, Liu J, Le X Chris, Han Y, Tong Y, Lau, ASY, Rong, J*, Pharmacological induction of LTB4 12-hydroxydehydrogenase (LTB4DH) suppresses the oncogenic transformation of human hepatoma HepG2 cells, International Journal of Oncology, 2011, 39(3):735-45. [IF: 2.5].
61. Cui W, Li W, Zhao Y, Mak S, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han Y, Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone. Brain Res. 2011, 1394:14-23. [IF: 2.45].
62. Qi H, Siu SO, Chen Y, Han Y, Chu IK, Tong Y, Lau ASY, Rong J*, Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1, Chem Biol Interact. 2010, 183(3):380-9. [IF: 2.46].
63. Qi HY, Wei L, Han YF, Zhang QL, Lau ASY, Rong J*, Proteomic characterization of the cellular response to chemopreventive triterpenoid astragaloside IV in human hepatocellular carcinoma cell line HepG2, International Journal of Oncology, 2010, 36(3):725-35. [IF: 2.5].
64. Lee DC, Yang CL, Chik SC, Li JC, Rong J, Chan GC, Lau AS, Bioactivity-guided identification and cell signaling technology to delineate the immunomodulatory effects of Panax ginsengs on human promonocytic U937 cells, J Translational Medicine, 2009, 7:34. [IF: 3.41].
65. Rong J*, Cheung CYH, Lau ASY, Shen JG, Tam PKH, Cheng YC, Induction of heme oxygenase-1 by traditional Chinese medicine formulation ISF-1 and its ingredients as a cytoprotective mechanism against oxidative stress, International Journal of Molecular Medicine, 2008, 21: 405-411. [IF: 1.98].
66. Cai GX, Liu BY, Liu W, Tan XH, Rong J, Chen XM, Tong L, Shen JG, Buyang Huanwu Decoction Can Improve Recovery of Neurological Function, Reduce Infarction Volume, Stimulate Neural Proliferation and Modulate VEGF and Flk1 Expressions in Transient Focal Cerebral Ischaemic Rat Brains, Journal of Ethnopharmacology, 2007, 113(2):292-9. [IF: 2.32].
67. Rong J*, Tilton R., Shen J, Ng KM, Liu C, Tam Paul KH, Lau Allan SY, Cheng YC, Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the selection of multiple marker genes as a potential metric for quality control. Journal of Ethnopharmacology, 2007, 113, 35-44. [IF: 2.32].
68. Rong J, Bleackley RC, Kane KP, Direct Detection of Cytolytic T Lymphocyte-Mediated Cytotoxicity on Antigen-Transfected Cell Microarray, Journal of Immunological Methods, 2007, 326(1-2):1-9. [IF:2.35].
69. Ewen CL, Rong J, Kokaji A, Bleackley RC, Kane KP, Evaluating antigen-specific cytotoxic T cell responses by a novel granzyme B ELISPOT assay, Journal of Immunological Methods; 2006, 308 (1-2):156-66. [IF: 2.34].
70. Rong J, Xu X, Ewen CL, Bleackley RC, Kane KP. Isolation of novel single-chain Fvs specific for human granzyme B, Hybridoma and Hybridomics, 2004, 23(4): 219-3. [IF: 1.2].
71. Rong J, Habuchi H, Kimata K, Lindahl U, Kusche-Gullberg M, Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase, Biochemistry, 2001, 40 (18), 5548-5555. [IF: 3.2].
72. Rong J, Novel chemical and enzymatic routes to the generation of heparin-related polysaccharides, Trends in Glycosciences and Glycotechnology, 2000, 12, 121-127. [IF: 1.53].
73. Rong J, Habuchi H, Kimata K, Lindahl U, Kusche-Gullberg M, Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation, Biochemical J. 2000, 346 (Pt 2), 463-8. [IF: 5.1].
74. Rong J, Nordling K, Björk I, Lindahl U, A novel strategy to generate biologically active neo-glycosaminoglycan conjugates, Glycobiology 1999, 9(12): 1331-6. [IF: 3.9].
75. Rong J, Roselt P, Plavec J, Chattopadhyaya J, The synthesis and conformation of 2'- and 3'-hypermodified tricyclic nucleosides and their use in the synthesis of novel 2'- or 3'-isomeric 4(7)-substituted isoxazolidine-nucleosides, Tetrahedron 1994, 50 (18), 4921-4936. [IF: 3.04].
76. Xi Z, Rong J, Chattopadhyaya J, Diastereospecific synthesis of 2'- or 3'-C-branched nucleosides through intra-molecular free-radical capture by silicon-tethered acetylene, Tetrahedron 1994, 50 (17), 5255-5272. [IF: 3.04].
77. Liu YY, Rong J, Xuan ZA, Wang ZF, Chen SS, Synthesis and catalytic property of poly(ß-chloroethyl glycidyl ether)-linked titanocene dichloride, CUIHUA XUEBAO (The Chinese J. of Catalysis) 13, 79-82 (1992), see American Chemical Abstract 116 : 194501w. [IF: 1.18].
78. Rong J, Liu YY, Chen SS, Preparation of pyrolyl metallic complexes and their applications in organic synthesis, YOUJI HUAXUE (The Chinese J. of Organic Chemistry), 12 (2), 113-25 (1992), see American Chemical Abstract 116: 235676c. [IF: 0.75].
79. Liu YY, Rong J, Xuan ZA, Wang ZF, Chen SS, Study on the synthesis and catalytic property of poly (phenyl ethers)-linked titanocene dichloride, HUAXUE SHIJI (Chem. Reagents), 13, 321- 322 (1991), see American Chemical Abstract 116: 151231r. [IF: 0.27].
80. Rong J, Liu YY, Chen SS, Synthesis of oxygen-bridged binuclear organotitanium complex (n-C4H9CpTiCl2)2O, HUAXUE TONGBAO (J. of Chinese Chem. Soc.), 42-43 (1991), see American Chemical Abstract 115: 206131u. [IF: 0.45].
81. Rong J, Use of ultrasonic waves in organic synthesis: Recent developments, HUAXUE TONGBAO (J. of Chinese Chem. Soc.), 8-14 (1991), see American Chemical Abstract 115: 28316z. [IF: 0.45].
82. Xuan ZA, Liu YY, Rong J, Wang ZF, Chen SS, Studies on the isomerization of Safrole catalyzed by titanohydrogen complexes, CUIHUA XUEBAO (The Chinese J. of Catalysis), 12, 59-64 (1991), see American Chemical Abstract 114: 185331x. [IF: 1.18].
83. Liu YY, Rong J, Xuan ZA, Wang ZF, Chen SS, Study on the synthesis and catalytic properties of polyether-linked Cp2TiCl2, YOUJI HUAXUE (The Chinese J. of Organic Chemistry), 529-534 (1990), see American Chemical Abstract 114: 163635x. [IF: 0.75].
84. Rong J, Liu YY, Electronic effects of titanohydrogenation reaction, HUAXUE TONGBAO (J. of Chinese Chem. Soc.), 25-32 (1990), see American Chemical Abstract 113: 230386m. [IF: 0.45].

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